Mestre - the gate of Venice

What else is convenient for Mestre - in one place is the railway station and bus stop, from which often leave the trains and buses to the "island" (only 15 minutes), the nearest airports, as well as the neighboring cities - Padua, Verona, Treviso, Bologna, in the Dolomite Alps or the Adriatic resorts.
Here, literally "across the street", you'll find many hotels, where with comfort and relatively inexpensive (compared to prices in Venice itself) can stay for a couple of nights and find parking. Most experienced travelers, especially those who travel with luggage or by car, do so.

Hotel Paris is one such option. A small, clean hotel with wi-fi and "Italian standard" expenses. In the neighborhood there are other hotels of about the same plan or more expensive. There's a lot to choose from.
Plan on staying here for two nights. In this case, you can check in even late at night and then have a full day to explore Venice. After a long and interesting walk, you can easily get back to your room, have a good rest and get some sleep before you continue your journey.

If you come to Mestre early enough, then after a check-in at the hotel and a little rest go for a walk in the city center. For tourists it is not as attractive as its famous neighbor, but as a "warm-up" is quite suitable. Especially since there you can definitely find a suitable restaurant for lunch or dinner.

I advise you not to stay too long on the walk. Come back to the hotel early and have a good rest. Tomorrow you'll have a difficult but very interesting day.